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butabarbital will minimize the extent or result of fedratinib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Steer clear of or Use Alternate Drug. Impact of coadministering a solid CYP3A4 inducer with fedratinib hasn't been researched.butabarbital will lower the level or impact of pioglitazone by influencing hepatic/intestinal enzyme CYP